The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.
Identifieur interne : 000897 ( Main/Exploration ); précédent : 000896; suivant : 000898The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.
Auteurs : Yuli Volovik [Israël] ; Filipa Carvalhal Marques [Portugal] ; Ehud Cohen [Israël]Source :
- Methods (San Diego, Calif.) [ 1095-9130 ] ; 2014.
English descriptors
- KwdEn :
- Aging (genetics), Aging (pathology), Alzheimer Disease (genetics), Animals, Caenorhabditis elegans (genetics), Caenorhabditis elegans (physiology), Humans, Models, Animal, Nerve Degeneration (genetics), Nerve Degeneration (pathology), Parkinson Disease (genetics), Parkinson Disease (pathology), Signal Transduction (genetics).
- MESH :
- genetics : Aging, Alzheimer Disease, Caenorhabditis elegans, Nerve Degeneration, Parkinson Disease, Signal Transduction.
- pathology : Aging, Nerve Degeneration, Parkinson Disease.
- physiology : Caenorhabditis elegans.
- Animals, Humans, Models, Animal.
Abstract
Toxicity arising from protein misfolding and aggregation (proteotoxicity) is tightly mechanistically linked to the emergence of late-onset neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Why these maladies manifest in late stages of life and what mechanisms protect the young organism from disease are key enigmas. The nematode Caenorhabditis elegans offers key advantages that enable systematic exploration of many cell biological and functional aspects of neurodegeneration-linked proteotoxicity. Here we review the abundantly used nematode-based proteotoxicity models and delineate common techniques for the measurement of protein aggregation and rate of proteotoxicity. We also discuss the advantages offered by the worm for genetic screening, drug development and for the exploration of the links between proteotoxicity and the aging process.
DOI: 10.1016/j.ymeth.2014.04.014
PubMed: 24794346
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000709
- to stream PubMed, to step Curation: 000709
- to stream PubMed, to step Checkpoint: 000709
- to stream Ncbi, to step Merge: 001748
- to stream Ncbi, to step Curation: 001748
- to stream Ncbi, to step Checkpoint: 001748
- to stream Main, to step Merge: 000899
- to stream Main, to step Curation: 000897
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.</title><author><name sortKey="Volovik, Yuli" sort="Volovik, Yuli" uniqKey="Volovik Y" first="Yuli" last="Volovik">Yuli Volovik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Marques, Filipa Carvalhal" sort="Marques, Filipa Carvalhal" uniqKey="Marques F" first="Filipa Carvalhal" last="Marques">Filipa Carvalhal Marques</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel; Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel; Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra</wicri:regionArea><wicri:noRegion>Coimbra</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Ehud" sort="Cohen, Ehud" uniqKey="Cohen E" first="Ehud" last="Cohen">Ehud Cohen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel. Electronic address: ehudc@ekmd.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24794346</idno><idno type="pmid">24794346</idno><idno type="doi">10.1016/j.ymeth.2014.04.014</idno><idno type="wicri:Area/PubMed/Corpus">000709</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000709</idno><idno type="wicri:Area/PubMed/Curation">000709</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000709</idno><idno type="wicri:Area/PubMed/Checkpoint">000709</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000709</idno><idno type="wicri:Area/Ncbi/Merge">001748</idno><idno type="wicri:Area/Ncbi/Curation">001748</idno><idno type="wicri:Area/Ncbi/Checkpoint">001748</idno><idno type="wicri:Area/Main/Merge">000899</idno><idno type="wicri:Area/Main/Curation">000897</idno><idno type="wicri:Area/Main/Exploration">000897</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.</title><author><name sortKey="Volovik, Yuli" sort="Volovik, Yuli" uniqKey="Volovik Y" first="Yuli" last="Volovik">Yuli Volovik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Marques, Filipa Carvalhal" sort="Marques, Filipa Carvalhal" uniqKey="Marques F" first="Filipa Carvalhal" last="Marques">Filipa Carvalhal Marques</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel; Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel; Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra</wicri:regionArea><wicri:noRegion>Coimbra</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Ehud" sort="Cohen, Ehud" uniqKey="Cohen E" first="Ehud" last="Cohen">Ehud Cohen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120, Israel. Electronic address: ehudc@ekmd.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University School of Medicine, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author></analytic><series><title level="j">Methods (San Diego, Calif.)</title><idno type="eISSN">1095-9130</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (genetics)</term><term>Aging (pathology)</term><term>Alzheimer Disease (genetics)</term><term>Animals</term><term>Caenorhabditis elegans (genetics)</term><term>Caenorhabditis elegans (physiology)</term><term>Humans</term><term>Models, Animal</term><term>Nerve Degeneration (genetics)</term><term>Nerve Degeneration (pathology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Signal Transduction (genetics)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term><term>Alzheimer Disease</term><term>Caenorhabditis elegans</term><term>Nerve Degeneration</term><term>Parkinson Disease</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Nerve Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Caenorhabditis elegans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Animal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Toxicity arising from protein misfolding and aggregation (proteotoxicity) is tightly mechanistically linked to the emergence of late-onset neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Why these maladies manifest in late stages of life and what mechanisms protect the young organism from disease are key enigmas. The nematode Caenorhabditis elegans offers key advantages that enable systematic exploration of many cell biological and functional aspects of neurodegeneration-linked proteotoxicity. Here we review the abundantly used nematode-based proteotoxicity models and delineate common techniques for the measurement of protein aggregation and rate of proteotoxicity. We also discuss the advantages offered by the worm for genetic screening, drug development and for the exploration of the links between proteotoxicity and the aging process.</div></front></TEI><affiliations><list><country><li>Israël</li><li>Portugal</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Volovik, Yuli" sort="Volovik, Yuli" uniqKey="Volovik Y" first="Yuli" last="Volovik">Yuli Volovik</name></noRegion><name sortKey="Cohen, Ehud" sort="Cohen, Ehud" uniqKey="Cohen E" first="Ehud" last="Cohen">Ehud Cohen</name></country><country name="Portugal"><noRegion><name sortKey="Marques, Filipa Carvalhal" sort="Marques, Filipa Carvalhal" uniqKey="Marques F" first="Filipa Carvalhal" last="Marques">Filipa Carvalhal Marques</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000897 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000897 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24794346
|texte= The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24794346" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |